AMERICAN PIT BULL TERRIER
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AMERICAN STAFFORDSHIRE TERRIERS
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HEART DISEASE



THIS SITE HAS BEEN CREATED TO MAKE YOU AWARE HOW PREVELENT HEART DISEASE IS IN AMSTAFFS. PLEASE REALIZE HOW IMPORTANT IT IS TO USE A CERTIFIED CARDIOLOGIST AND NOT A REGULAR VET WHEN CHECKING FOR THIS PROBLEM!!


PLEASE READ THIS INFORMATIVE ARTICLE BY PAM PERDUE TO START SO YOU UNDERSTAND THE PROBLEMS.
(THIS ARTICLE IS COPYWRITED AND MAY NOT BE COPIED WITHOUT PAM PERDUE'S PERMISSION)

The Heart of the Matter

Pamela Perdue, Owner/Breeder since 1988 (p_perdue@yahoo.com)

The American Staffordshire Terrier is unequivocally a breed of heart and soul. A breed willing to give their life to the ones they love. They don't know when to quit or give up. With all this personality and strength we must take the time to protect the health and soundness of our Amstaffs.
In previous articles I have attempted to provide information on tools available to owners, breeders, and handlers to help evaluate the health of our beloved breed. A very recent experience has prompted me to write this article. The topic of health issues bores some and denied by others. I ask for your time to read this article and to think about the future of the Amstaff.
My enlightenment came after several phone calls from "interested & concerned" breeders. They were interested in a litter I produced from a frequently used Sire. Upon further discussion, the individuals shared their genuine concern for the breed. At the time, the litter under discussion was now 2 years old, all hips OFA good (4 that I owned), all AKC pointed and one finished. All were a picture of health, high drive, endurance and standard sized (18" bitches, 50-55lbs, 19" males 60lbs). I questioned what possibly could be wrong. Then I was told I was "lucky" so far, their litters were dropping dead at 3 years old!!! How could this be? Seemingly healthy dogs dropping dead? My mind was spinning. All of their dogs had necropsies with the same diagnosis, their hearts exploded! After very little research, the pieces of the puzzle came together. It wasn't just one person's litter affected, many are known now, including one of my babies, now 4 years old.
Over the years I have learned to listen, analyze and validate truth from fiction and exaggerations. This article is my attempt to share information that can be used as another tool for the informed. If you chose to acknowledge the problem, then you will learn from others experiences; otherwise it is inevitable that you will learn the HARD WAY and the breed will suffer.
I am thankful to the people who called to enlightened me to a hidden killer. Heart problems are very common and serious in our Amstaffs. That said, I will attempt to summarize the Heart "gotchas" known to this breed.
What is Heart Disease in Dogs?
Heart disease in dogs, as in people can be either present at birth or acquired, often developing during middle age. Acquired heart disease is more common, affecting many older dogs.
There are two common types of heart disease in dogs:
· The heart valves lose the ability to close properly, causing abnormal blood flow.
· The muscular walls of a dog's heart become thinned and weakened.
What are the signs of heart disease?
Signs of heart disease in dogs may be mild and difficult to notice at first, but can become more severs as the disease progresses.
A list of symptoms include:
· Lack of energy
· Labored breathing
· Lack of appetite and weight loss
· Frequent coughing
· Weakness in rear
· Fainting
· Abdominal swelling
· In some cases no symptoms are noticed and death occurs suddenly
How can you find out if your dog has heart disease?
Though regular veterinary visits can pick up "some" of the more severe murmurs, it is recommend that a cardiologist be consulted for full body auscultation. Doppler echocardiography and EKG (two dimensional) tests are recommended for the most conclusive results.
Echocardiography refers to the imaging of the heart with ultrasound. This is the same technology used in man to examine the pregnant uterus. The Doppler involves the detection and velocity of blood flow throughout the heart.
The normal peak velocity of blood flow across the four valves in the heart has been determined in the dog:
Tricuspid valve = .9 meters/sec
Mitrial valve = 1.1 meters/sec
Pulmonic valve = 1.2 meters/sec
Aortic valve = 1.5 meters/sec
Can heart disease be treated?
Yes in most cases. Although there is no cure for most heart disease in dogs, new treatments are available. Success of treatment depends on various factors, but early detection is always best.
Use the following diagrams to help clarify the information contained in the following detailed explanations of cardiac disorders and diagnostics:





What are common heart problems in Amstaffs?
Patent ductus arteriosus (PDA):
The problem is the failure of the ductus arteriosis to close shortly after birth and thereby allows continued flow of blood between the aorta and pulmonary artery.
This was originally though to be the most frequently encountered congenital cardiac defect in all dogs. It is now believed by cardiologist that aortic stenosis is the most common.
Usually this condition presents itself at 6 to 12 weeks of age and is more common in females. Signs of heart failure are usually absent. Often a prominent pulse may be noted in many unusual areas on the body (ie. Gums) A continuous murmur is present.
Prognosis:
Treatment for PDA is via surgical correction or coil occlusion. In the hands of a skilled surgeon the survival rate is 90%. Without surgery, it is estimated, though not substantiated, that 60% will die by 1 year.
Aortic Stenosis (AS):
AS is the most common congenital cardiac defect and most difficult to diagnose in the dog. The stenotic lesion may occur in the subvalvular position, valvular position or supravalvular position. The subvalvular is the most common in dogs.
This has been documented in many breeds, including Bull Terriers. It should be noted this is the most common condition that causes the exploding hearts in our Amstaffs. The genetic factor(s) of AS are not known as of yet. It is believed to be polygenetic, and therefore very difficult to eliminate from the gene pool. Only through the testing of all breeding stock and strict culling of positive animals and producers of positive animals are there hopes to eventually eliminate this condition.
AS can be present at birth or develop up to one year of age. It has not been documented to develop in dogs over 1 year. it can be present as adults with an incidental murmur. Signs of heart failure are rare. Dysrhythmias with pulse deficits may be noted. Systolic heart murmur is located over left heart base and radiates of the neck and to the right hemothorax.
Definitive diagnosis can be done via Doppler echocardiography or Cardiac catheterization. EKG will show normal and diagnosis for AS is inconclusive. A presumptive diagnosis can be done via ausculation of a left systolic heart murmur with a weak femoral arterial pulse.
Treatment includes beta blockers (though they are controversial) or very limited surgical options. Though heart failure is rare, it is more likely to occur in cases of moderate and severe AS if concurrent mitral valve insufficiency is present and severe.
Prognosis:
· Most cases of AS of marked severity result in sudden death.
· Mild cases of AS live a full life (both normal quality and duration)
· Even cases of moderate stenosis can anticipate a life of normal length and quality.
· Work with Doppler echocardiography has revealed that if the velocity of flow across the left ventricular outflow is less than 4 m/s by the time the dog is mature, it appears that the dogs can anticipate a life of normal length and quality. If the velocity is greater than 5 m/s it will likely succumb to this disorder.
· Progression of AS is very slow in mature dogs.
· It has been reported that if dogs survive with AS beyond 3 years, they usually do not have AS severe enough to produce a marked effect on left valve performance.
Dogs with this condition should be strictly culled from breeding programs!
Pulmonary Stenosis (PS):
PS is the third most prevalent cardiac disorder in the dog. A stenotic lesion may occur in subvalvular, valvular or supravalvular position. The valvular disorder is the most common in dogs.
Symptoms include fatigue and exercise intolerance. A definitive diagnosis for PS is via the Doppler echocardiography or Cardiac catherization test. EKG provides insight into the disorder. A presumptive diagnosis can be made via ausculation of a left basilar systolic heart murmur with a normal femoral arterial pulse. Dilation of the main pulmonary artery on thoracic radiographs may be seen.
The treatment of choice for severe PS is surgical correction. However the efficacy of surgical intervention remains to be substantiated. Medication to control dysrhythmias and fluid around the heart may also be an option.
Prognosis:
Mild cases can be expected to live a full life with this abnormality. Severe cases of PS may die suddenly or develop signs of right heart failure and die in 6-12 months.
Ventricular Septal Defect (VSD):
This abnormality is a defect allowing blood flow between the left and right ventricle. This defect usually presents itself in puppies. A large defect will stunt growth and the pup will fail to thrive.
A definitive diagnostic test for VSD is via Doppler or Cardiac catheterization. A presumptive diagnosis can be made by ausculation of a right sternal border systolic heart murmur or radiographic evidence of pulmonary overcirculation.
Symptoms include reduced exercise tolerance, fatigue, possible heart murmur and jugular distention.
Treatment for mild VSD requires no therapy, whereas severe VSD requires surgical repair. Prognosis for severe VSD if pulmonary hypertension develops is very poor.
Cardiomyopathy:
Cardiomyopathy is a term used to describe a condition that occurs to the heart muscle, when one or more diseases cause inflammation and scarring. This inflammation and scarring causes an enlargement of the heart itself, and the chambers within the heart dilate and become less efficient in supplying the body and organs with blood. The end result of a dog suffering from this condition is that the heart muscle will eventually weaken and the dog will develop congestive heart failure and die.
A definitive diagnostic test for VSD is via Doppler or Cardiac catheterization. A presumptive diagnosis can be made by ausculation.
The exact method of inheritance is not yet documented, however, the disease appears to be very breed specific. The breeds with documented history of Cardiomyopathy: Boxers, Cocker Spaniels, Doberman, German Shepherd, Golden Retriever, Great Dane, Irish Wolfhounds and Saint Bernards.
Since we do not have any breed specific documentation on the Amstaff on any inherited heart problem, I do not consider our breed immune.
Most of the research has been done on Dobermans and show that males do not show symptoms until the disease becomes severe around 5 to 8 years of age. Females are asymptomatic until nine to twelve. Once the clinical signs of lethargy, weight loss, cough, exercise intolerance and shortness of breath appear, the heart is beginning to fail.
Other Congenital Disorders:
Routine EKG and Doppler are useful to detect intracardiac shunts and dysplasia of the mitral and tricuspid valves. The incidence of tricuspid valve insufficiency, as determined by Doppler, has been reported to be approximately 50% in normal dogs. A dog will die with this condition, not of it according to Dr. Mussleman, DVM, Cardiologist. Pulmonic valve insufficiency occurs in 25 to 70% of normal dogs. Most dogs over 4 or 5 have these types of conditions and it is a normal part of aging. The presence of a murmur does not equate with heart failure. In fact, most patients with a heart murmur do not have heart failure.
Mitral Valve Dysplasia:
The most common disorder of the mitral valve is the partial backflow (regurgitation) of blood through the valve. Regurgitation is usually the result of valvular degeneration, which occurs most often in older members of the smaller dog breeds. Severe mitral regurgitation, not only produces significant increases in the left side of the heart, it is frequently accompanied by varying degrees of congestive heart failure.
Tricuspid Valve Dysplasia (TVD):
This valve is located between the right atrium and the right ventricle of the heart. The purpose of this valve is to control the backflow of blood during contractions of the heart.
During normal fetal development, the tricuspid valve flaps are adhered to the wall separating atrium from ventricle. As the fetal development progresses under normal circumstances the adhesive bonds holding the valve open will degenerate, allowing the valve flaps to move into their proper position.
One of the primary causes of TVD is the failure of the bond to degenerate. Depending on the severity of the malformation, the work on the right side of the heart increases.
Symptoms of TVD are dependent upon the extent of the malformation, but some of the most common symptoms re: fluid retention, cool extremities and exercise intolerance (possibly followed by collapse).
TVD in dogs is usually congenital (present at birth). Due to the fact that this condition (when it occurs) appears in several littermates, and tends to be more prevalent in some family bloodlines than others, it is suspected that the tendency to have this birth defect is hereditary. It is hoped that through screening of breeding stock and their lineage (parents, grandparents, littermates, aunts, uncles, etc) efforts can be made to eliminate susceptible bloodlines from breeding programs.
What causes Heart Murmurs?
· Insufficient valves, stenotic valves, interatrial and interventricular defects (holes), and arterial venous communications (PDA) cause murmurs. · If the viscosity of blood is decreasedàmurmur; if the viscosity is increasedàmurmur is masked!
Anything that muffles the heart sounds can obscure a murmur such as obesity, thoracic effusions, loud breathing/panting or heavy muscle walls.
Heart murmurs can occur in the absence of disease in the growing young dog. These are normally referred to as innocent murmurs. They should resolve by 6 months of age. These murmurs usually occur over the left ventricular outflow tract, are of low intensity (grade 1/6 or 2/6) and occur early in the heart beat.
Murmurs are classified based on their intensity.
· Mild: only detected after careful ausculation (grade 1/6, 2/6)
· Moderate: detected readily at the onset of auculation but no thrill is present (grade 3/6, 4/6)
· Marked: readily detected at onset of ausculation and a thrill is palpable (grade 5/6, 6/6)
In general, the intensity of a murmur does not reflect the severity of the etiology.
Breeds with Documented Congenital Heart Disease (CHD):
Reviewing the documentation on other bull and/or terrier breeds the predominant CHD is Aortic Stenosis (includes Sub Aortic Stenosis), Mitrial & Tricuspid valve dysplasia, and Pulmonary Stenosis.
Orthopedic Foundation for Animals (OFA) has more information posted on their website as well as a source to find cardiac clear Amstaffs and other breeds. It is important that we use the knowledge and tools available to improve the future for the American Staffordshire Terrier. Consider the total package and the heart of the matter before selecting future breeding prospects. What choices you make impacts the future of the breed.
Research Credits:
American Veterinary Medical Association
Veterinary Cardiology of California
Orthopedic Foundation for Animals


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